Effect of growth hormone on insulin secretion.

نویسندگان

  • W J Malaisse
  • F Malaisse-Lagae
  • S King
  • P H Wright
چکیده

MALAISE, WILLY J., FRANCXNE MALAISSE-LAGAE, SUZANNE KING, ANII PETER H. WRIGHT. Efect of growth hormone on insulin secretion. Am. J. Physiol. 215(2) : 4-23-428. 1968.pInsulin secretion by pancreatic tissue or isolated islets of the normal rat is not affected by addition of ovine or rat growth hormone to the incubation medium. Pancreatic tissue removed from hypophysectomized rats secretes an abnormally low amount of insulin in response to stimulation by glucose; such secretion rises towards the normal after treatment of the rat for 4 days with ovine growth hormone in vivo. Implantation of a growth hormone-secreting tumor into the normal rat increases rate of growth, the store of pancreatic insulin, and the rate of insulin secretion induced by glucose in vitro. These findings are discussed and it is suggested that growth hormone may play a role in the normal development of islet function.

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عنوان ژورنال:
  • The American journal of physiology

دوره 215 2  شماره 

صفحات  -

تاریخ انتشار 1968